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近年发现,特发性肺间质纤维化患者罹患肺癌的发生率逐年增高,但因特发性肺间质纤维化合并肺癌(IPF-LC)缺乏特异的临床表现、血液学及影像学特征,增加了诊断的难度.同时IPF-LC患者常因肺功能差而无法耐受放化疗,使其治疗方案的选择受到限制,并且放化疗以及靶向治疗等措施又会加重肺纤维化的进程,导致IPF-LC治疗难度加大,预后不佳.本文旨在对IPF-LC的流行病学、发病机制、临床特点及治疗方案的相关研究进行综述.“,”In recent years,the incidence of idiopathic pulmonary fibrosis in patients with lung cancer increased year by year.However,the diagnosis and treatment of idiopathic pulmonary fibrosis with lung cancer (IPF-LC) is difficult because of the lack of specific clinical manifestations,hematological and imaging features.IPF-LC patients often can not tolerate chemotherapy due to poor pulmonary function and other reasons,so the treatment options are limited.On the other hand,radiotherapy,chemotherapy and targeted treatment will increase the process of pulmonary fibrosis,leading to the treatment difficulties and poor prognosis.This study aims to summarize the epidemiology,pathogenesis,clinical features and treatment of IPF-LC.