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[目的]探讨不同移植方法体外受精-胚胎移植（IVF-ET ）后异位妊娠相关因素。[方法]收集2006年9月至2008年12月（常规移植推注方法，A组）与2009年1月至2012年6月（改良移植推注方法，B组）接受IVF-ET获得临床妊娠患者的临床资料，比较不同移植推注方法的异位妊娠率，分析异位妊娠的影响因素。[结果]B组异位妊娠率（2．69％）较A组（7．84％）显著性降低（ P＜0．01）；改良移植推注方法（OR＝0．428，P＜0．01）、HCG时子宫内膜厚度≥8 mm（OR＝0．521，P＜0．01）是降低IVF-ET后异位妊娠的独立保护因素。[结论]在一定程度上改进移植推注方法和增加HCG日子宫内膜厚度可明显降低IVF-ET后异位妊娠率。“,”[Objective]To explore the related factors of ectopic pregnancy after in vitro fertilization and embryo transfer (IVF-ET) .[Methods]Clinical data of patients receiving routine IVF-ET(group A) from Sept .2006 to Dec .2008 and pa-tients receiving the modified IVF-ET(group B) from Jan .2009 to June 2012 were collected .Ectopic pregnancy rate of differ-ent embryo transfer methods was compared .The related factors of ectopic pregnancy were analyzed .[Results]Compared with group A ,ectopic pregnancy rate in group B was markedly decreased (7 .84% vs .2 .69% )( P<0 .01) .The modified embryo transfer method (OR=0 .428 ,P<0 .01) and HCG endometrial thickness (OR=0 .521 ,P<0 .01) were the independent pro-tective factors to decrease ectopic pregnancy rate after IVF-ET .[Conclusion]To a certain extent ,improving embryo transfer method and increasing endometrial thickness on HCG day can obviously decrease ectopic pregnancy rate after IVF-ET .