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目的:探讨炎性标记物白介素-18和白细胞计数在不同程度的冠状动脉病变中的表达情况,以期根据炎性标记物的血浆水平甄别冠状动脉病变的严重程度。方法:测定经冠脉造影确诊的急性冠脉综合征(ACS)病人血浆中白介素- 18(IL-18)的含量以及全血白细胞计数,然后比较不同程度冠脉病变组的炎性标记物水平;并比较糖尿病(DM)组和非DM组的差异。结果:白介素-18的含量以及全血白细胞计数在冠状动脉复杂病变组明显高于简单病变组(P <0．05)。合并有DM的ACS病人白介素-18的含量以及全血中的白细胞计数水平明显高于非DM组(P<0．05)。结论:在不同程度的冠状动脉病变组和不同危险因素组炎性标记物水平存在着显著性差异。
Objective: To investigate the expression of interleukin-18 (IL-18) and leukocyte count (CML) in patients with varying degrees of coronary lesions in order to screen the severity of coronary lesions according to the plasma levels of inflammatory markers. Methods: The levels of interleukin - 18 (IL - 18) in plasma and white blood cell count (WBC) of patients with acute coronary syndrome (ACS) confirmed by coronary angiography were measured. Then the levels of inflammatory markers in different degree of coronary artery disease were compared ; And compared the difference between DM group and non-DM group. Results: The levels of interleukin-18 and whole blood leukocyte count in patients with complicated coronary lesions were significantly higher than those in patients with simple lesions (P <0.05). The levels of interleukin-18 and whole blood leukocyte counts in ACS patients with DM were significantly higher than those in non-DM patients (P <0.05). Conclusion: There are significant differences in the levels of inflammatory markers in different degrees of coronary artery disease group and different risk factors group.