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奥美哌唑(Omeprazole)是抑制胃酸分泌的一种新药,其母体为硫氧化苯骈咪哇。它通过血浆横跨胃壁细胞胞浆而进入分泌小管,继与壁细胞H~+—K~+ATP酶结合,转变为一种具有活性的复合物,从而抑制氢离子(H~+)分泌进入胃腔。该药在酸中不稳定,常配制成肠溶颗粒的缓释硬胶囊。约有50％剂量进入体循环,其中95％与血浆蛋白结合。循环中的药物主要在肝内代谢,经胆汁和尿液排出体外。服用奥美哌唑后1h即可抑制胃液的酸度,2h达高峰,24h后仍可最高作用的一半,其抑制作用可持续3d。
Omeprazole (Omeprazole) is a new drug that inhibits gastric acid secretion, the mother body of sulfonylurea sulfoxide microphone. It passes through the cytoplasm of gastric parietal cells and enters the secretion tubules, and then binds to the parietal cells H ~ + -K ~ + ATPase and changes into an active complex, thereby inhibiting the secretion of hydrogen ions (H ~ +) Gastric cavity. The drug instability in the acid, often formulated into enteric-coated granules slow-release hard capsules. About 50% of the dose into the systemic circulation, of which 95% and plasma protein binding. Cyclic drugs are mainly metabolized in the liver, excreted by the bile and urine. After taking omeprazole 1h can inhibit the acidity of gastric juice, reached the peak at 2h, still can be half of the maximum effect after 24h, the inhibitory effect of sustainable 3d.