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2(5H)-呋喃酮作为一种α,β-不饱和环丁内酯,可发生多种反应,特别是其不饱和碳碳双键上连有卤素时,2(5H)-呋喃酮的高反应性使其被广泛应用于有机合成.按照反应后五元环内酯产物上取代基位置的不同,综述了2(5H)-呋喃酮与含氮亲核试剂通过Michael加成、串联的Michael加成-消除、偶极环加成和钯催化耦合等反应合成β-取代、α,β-取代和γ-取代环状衍生物在近十几年的研究进展.
2 (5H) -furanone as an α, β-unsaturated cyclobutyrolactone, a variety of reactions can occur, especially the unsaturated carbon-carbon double bond with halogen, 2 (5H) - furanone High reactivity makes it widely used in organic synthesis.According to the difference of the substituents on the five-membered ring lactone products after reaction, the synthesis of 2 (5H) -furanone and nitrogen-containing nucleophile by Michael addition, Recent research progress in synthesis of β-substituted, α, β-substituted and γ-substituted cyclic derivatives by Michael addition-elimination, dipolar cycloaddition and palladium-catalyzed coupling reactions has been reported.