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目的探讨小剂量阿司匹林联合硫酸镁治疗妊娠期高血压疾病对患者血清TNF-α、IL-6、IL-10水平的影响。方法将妊娠期高血压疾病患者220例随机分为观察组和对照组各110例。观察组给予小剂量阿司匹林联合硫酸镁治疗,对照组单纯给予硫酸镁治疗。治疗前后观察2组患者血清TNF-α、IL-6、IL-10水平变化,比较2组治疗前后血黏度、血细胞压积、S/D、RI指标情况。结果治疗后2组患者的血清TNF-α、IL-6低于治疗前,血清IL-10水平高于治疗前,血黏度、S/D、RI低于治疗前,血细胞压积大于治疗前,且观察组变化幅度大于对照组,差异均有统计学意义(P<0.05)。结论小剂量阿司匹林联合硫酸镁治疗妊娠期高血压疾病能有效改善患者症状,可显著改善炎性细胞分子紊乱,值得临床推广应用。
Objective To investigate the effect of low-dose aspirin combined with magnesium sulfate on the serum levels of TNF-α, IL-6 and IL-10 in patients with gestational hypertension. Methods 220 cases of hypertensive disorders of pregnancy were randomly divided into observation group and control group of 110 cases. The observation group was treated with low-dose aspirin combined with magnesium sulfate, while the control group was treated with magnesium sulfate alone. The changes of serum TNF-α, IL-6 and IL-10 levels in two groups before and after treatment were observed. The blood viscosity, hematocrit, S / D and RI were compared between the two groups before and after treatment. Results The levels of serum TNF-α and IL-6 in two groups were lower than those before treatment, and the level of serum IL-10 was higher than before treatment. The blood viscosity, S / D and RI were lower than before treatment, The changes in the observation group were greater than those in the control group, with significant differences (P <0.05). Conclusion Low-dose aspirin combined with magnesium sulfate in the treatment of gestational hypertension can effectively improve the symptoms of patients and significantly improve the molecular disorder of inflammatory cells, which is worthy of clinical application.