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目的观察清热解毒口服液在BALB/c小鼠体内抗甲型流感病毒的作用。方法将BALB/c小鼠随机均分为正常对照组、流感病毒感染模型组、利巴韦林片组、连花清瘟胶囊组及清热解毒口服液高、中、低剂量组。小鼠感染流感病毒后ig给药,以生存情况、死亡保护率及延长生命率作为指标,观察清热解毒口服液抗流感病毒的作用。结果清热解毒口服液各剂量组均能减轻感染小鼠的发病症状;死亡保护率为50%～60%;延长生命率为61.56%～73.84%。与阳性药物利巴韦林片及连花清瘟胶囊比较,差异无统计学意义。结论清热解毒口服液在BALB/c小鼠体内有抗甲型H1N1流感病毒的作用,其机制有待深入研究。
Objective To observe the effect of Qingrejiedu oral liquid on influenza A virus in BALB / c mice. Methods BALB / c mice were randomly divided into normal control group, influenza virus infection model group, ribavirin tablet group, Lianhua Qingwen Capsule group and Qingrejiedu oral liquid high, medium and low dose groups. Mice were infected with influenza virus after ig administration, survival, death protection and prolongation of life as an indicator to observe the Qingrejiedu oral anti-influenza virus. Results Qingrejiedu oral solution of each dose group can reduce the incidence of symptoms in mice infected; death protection rate of 50% to 60%; prolongation of life was 61.56% ~ 73.84%. Compared with the positive drug ribavirin tablets and even Huaqingwen capsules, the difference was not statistically significant. Conclusion Qingrejiedu oral solution has anti-influenza A (H1N1) virus in BALB / c mice. The mechanism needs further study.