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目的 ]了解HBV不同感染模式产妇血液、脐血、乳汁HBVDNA感染状况。 [方法 ]对 1994年 8月至 1998年 8月在潍坊市人民医院分娩的 94例HBsAg阳性产妇和 46例HBsAg阴性产妇血液、脐血、乳汁进行了HBVDNA检测。 [结果 ] 94例HBsAg阳性产妇血液、脐血、乳汁HBVDNA阳性率分别为 5 1 0 6%、3 9 3 6%、2 9 79% ,46例对照均阴性 ,两组差异有高度显著性。在HBsAg阳性产妇中又以HBsAg、HBeAg或再加抗 -HBc感染模式血液、脐血、乳汁阳性率最高 ,分别为 84 0 9%、70 45 %、5 4 5 5 %。 [结论 ]提示HBsAg、HBeAg或再加抗 -HBe感染模式产妇作为传染源意义最大 ,分娩过程中应加强婴儿保护 ,2 4h内接种乙肝疫苗 ,最好不实行母乳喂养 ,且母婴隔离。
Objectives: To understand the status of HBV DNA infection in maternal blood, umbilical cord blood and breast milk of HBV with different infection patterns. [Methods] HBV DNA was detected in 94 cases of HBsAg-positive mothers and 46 cases of HBsAg-negative mothers who were delivered from August 1994 to August 1998 in Weifang People’s Hospital. [Results] The positive rates of HBV DNA in blood, umbilical cord blood and breast milk of 94 HBsAg positive parturients were 5-106%, 3936%, 2999% respectively. The 46 controls were all negative. The difference between the two groups was highly significant. Among HBsAg-positive mothers, the positive rates of HBsAg, HBeAg, or anti-HBc infection blood, umbilical cord blood, and milk were the highest, which were 84 0 9%, 70 45 %, and 5 4 5 5 %, respectively. [Conclusion] It is suggested that the HBsAg, HBeAg, or anti-HBe infection pattern has the greatest significance as the source of infection. The infant protection should be strengthened during the delivery process. Hepatitis B vaccine should be administered within 24 hours. It is better not to breastfeed and isolate the mother and infant.