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房室结传导的加速性、疲劳性对心室免于各种类型的室上性心动过速包括心房颤动的影响起决定作用，但对房室结功能不应期（ＡＶＮ－ＦＲＰ）的影响不明。旨在通过对离体兔心施以多种方案电生理刺激以阐明两者的相互关系。实验结果表明：①房室结传导的加速性使ＡＶＮ－ＦＲＰ缩短（Ｂ方案１４６±３．３ｍｓｖｓＡ方案１５９±３．５ｍｓ，Ｐ＜０．０１，ｎ＝６），疲劳性使ＡＶＮ－ＦＲＰ延长（Ｃ方案１８７±４．９ｍｓｖｓＡ方案１５９±３．５ｍｓ，Ｐ＜０．０１，ｎ＝６）；②加速性和疲劳性诱导的ＡＶＮ－ＦＲＰ的变化是在１１房室传导范围内产生的，并在快速频率下达到它的最大效应（１００％频率下，Ｂ方案１５４±６．０ｍｓ、Ｃ方案１８７±８．３ｍｓ分别与Ａ方案１６８±６．９ｍｓ相比，Ｐ均＜０．０１，ｎ＝６）。结论：ＡＶＮ－ＦＲＰ受房室结传导之加速性、疲劳性相互作用的共同影响，ＡＶＮ－ＦＲＰ的变化可以用来反映房室结的传导功能
Atrioventricular node conduction acceleration and fatigue play a decisive role in the ventricular response to various types of supraventricular tachycardias, including atrial fibrillation, but the effect on AVN-FRP is unknown . The aim is to clarify the interrelation between the two by giving various schemes of electrophysiological stimulation to isolated rabbit hearts. The results showed that: (1) AVN-FRP was shortened by the acceleration of atrioventricular node conduction (B ± 146 ± 3.3ms vs A ± 159 ± 3.5ms, P <0.01, n = 6) (C program 187 ± 4.9msvsA program 159 ± 3.5ms, P <0.01, n = 6); ② acceleration and fatigue induced changes in AVN-FRP is produced in the 11 atrioventricular conduction range, And reached its maximal effect at a fast frequency (P <0.05 for B program 154 ± 6.0 ms at 100% frequency, P <0.01 for C ± program 187 ± 8.3 ms vs 168 ± 6.9 ms for A program, respectively) n = 6). CONCLUSIONS: The AVN-FRP is influenced by the acceleration and fatigue interaction of atrioventricular node. The change of AVN-FRP can be used to reflect the conduction function of atrioventricular node