论文部分内容阅读
目的对男男性接触者(MSM)艾滋病病毒(HIV)感染者和艾滋病(AIDS)病人HLA-B不同基因型的分布及其与疾病进展相关性进行研究,探讨HLA-B基因在MSM HIV/AIDS疾病进程中的作用。方法根据患者从HIV感染到AIDS发病的时间不同分为快速进展组(RP)和非快速进展组(NRP),对两组HIV/AIDS MSM的HLA-B位点的等位基因分型,分析HLA-B基因型与AIDS疾病进展相关性。结果 219例MSM HIV/AIDS,快速进展组(RP)60人(27.40%)和非快速进展组(NRP)159人(72.60%)。中位潜伏期为5.73年(95%CI 5.32~5.94年)。其中RP组中位潜伏期为3.82年(95%CI 3.51~4.35年),NRP组中位潜伏期为6.67年(95%CI 5.51~7.18年)。HLA-B*27和HLA-B*51等位基因NRP组分布大于RP组,HLA-B*35等位基因RP组分布大于NRP组,(P均<0.05)。结论 HLA-B对MSM感染HIV后病程进展有相关性,其机制值得进一步深入研究。
OBJECTIVE: To study the distribution of HLA-B genotypes in MSM and AIDS patients and its relationship with disease progression, and to explore the relationship between HLA-B gene polymorphism and MSM HIV / AIDS The role of the disease process. Methods According to the time from HIV infection to AIDS, the patients were divided into rapid progression group (RP) and non-rapid progression group (NRP). The allelic genotypes of HLA-B loci in two groups of HIV / AIDS MSM were analyzed HLA-B genotype and AIDS disease progression. Results A total of 219 MSM HIV / AIDS patients, 60 (27.40%) patients in rapid progression group (RP) and 159 (72.60%) patients in non-rapid progression patients group (NRP). The median incubation period was 5.33 years (95% CI 5.32-5.44 years). Among them, the median latency of RP group was 3.82 years (95% CI 3.51-4.35 years), and the median latency of NRP group was 6.67 years (95% CI 5.51-7.18 years). The distribution of HLA-B * 27 and HLA-B * 51 alleles in the NRP group was greater than that in the RP group. The distribution of HLA-B * 35 alleles in the RP group was greater than that in the NRP group (all P <0.05). Conclusion HLA-B is associated with the progression of MSM infection after HIV infection, and its mechanism deserves further study.