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目的观察多巴胺、多巴酚丁胺联合硝普钠治疗顽固性心力衰竭的临床疗效。方法将50例顽固性心力衰竭患者随机分成对照组和治疗组,均给予常规常规给予吸氧、休息、限盐、抗感染,强心、利尿及扩血管治疗,对照组25例继续常规予洋地黄类、利尿剂、硝酸酯类,血管紧张素转换酶抑制剂(ACEI)治疗;治疗组25例予多巴胺、多巴酚丁胺联合硝普钠微量泵静脉注入,两组疗程均为7天,观察两组临床症状、体征、心脏彩超等变化。结果治疗组总有效率88.0%,对照组总有效率75.0%,总有效率两组对比差异有统计学意义(x2=3.87,P<0.05)。治疗后治疗组左室射血分数(LVEF)较对照组明显改善,差异有统计学意义(t=9.24,P﹤0.01)。结论多巴胺、多巴酚丁胺联合硝普钠治疗顽固性心力衰竭是安全有效的。
Objective To observe the clinical effect of dopamine, dobutamine combined with sodium nitroprusside in the treatment of refractory heart failure. Methods Fifty patients with refractory heart failure were randomly divided into control group and treatment group. All patients were given conventional routine oxygen inhalation, rest, salt-limited, anti-infective, cardiotonic, diuretic and vasodilator therapy. Rehmannia, diuretics, nitrates and angiotensin-converting enzyme inhibitor (ACEI). In the treatment group, 25 cases were treated with intravenous injection of dopamine, dobutamine and nitroprusside. The treatment courses were for 7 days The changes of clinical symptoms, signs and color Doppler echocardiography were observed. Results The total effective rate was 88.0% in the treatment group and 75.0% in the control group. The total effective rate was significant difference between the two groups (x2 = 3.87, P <0.05). The left ventricular ejection fraction (LVEF) of the treatment group after treatment was significantly higher than that of the control group (t = 9.24, P <0.01). Conclusions Dopamine, dobutamine and sodium nitroprusside are safe and effective in treating refractory heart failure.