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目的:探讨美托洛尔的药理特性及不良反应。方法:选择2013年1月-至2015年12月间,从国家药品不良反应监测系统网站,选取应用美托洛尔出现的不良反应的住院患者56例作为研究对象,对病例的临床资料展开回顾性分析,并总结美托洛尔的药理特性。结果:本组56例不良反应患者中,男性所占比例高于女性(P<0.05),年龄40~69岁。不良反应涉及系统较多,以心血管系统最为常见(P<0.05)。结论:美托洛尔为新型降压药,其属于β1受体阻滞剂,临床效果显著,然会引发一定程度的不良反应,用药过程中应给予高度重视。
Objective: To investigate the pharmacological properties and adverse reactions of metoprolol. Methods: From January 2013 to December 2015, 56 patients hospitalized with adverse reactions of metoprolol were selected from the national ADR monitoring system website as the research object, and the clinical data of the cases were reviewed Sex analysis, and summarize the pharmacological properties of metoprolol. Results: Among the 56 patients with adverse reactions, the proportion of males was higher than that of females (P <0.05), and the ages ranged from 40 to 69 years. More adverse reactions involving the system, the most common cardiovascular system (P <0.05). Conclusion: Metoprolol is a new type of antihypertensive drugs, which belong to β1 blockers, the clinical effect is significant, it will lead to a certain degree of adverse reactions, medication should be given great importance.