由乙酰胆碱介导引起内皮细胞释放内皮衍生舒张因子，通过激活环磷酸鸟苷的作用，使血管平滑肌松弛。内皮细胞随增龄而减少，新生的再生内皮细胞失去其原有的正常内皮功能，从而促发心血管疾病的发生和发展；而抑制血管紧张素转换酶，一方面可以促使肾素－血管紧张素系统中，血管紧张素Ⅱ／血管紧张素Ⅰ的比值下降，另一方面通过缓激肽的作用促使ＥＤＲＦ的释放，使其在心血管疾病中起到进一步的有益作用。 Acetylcholine-mediated endothelial cell-derived release of endothelial-derived relaxing factor, by activating the role of cyclic guanosine monophosphate, so that smooth muscle relaxation. Endothelial cells decreased with age, newborn endothelial cells lose their normal endothelial function, thereby contributing to the occurrence and development of cardiovascular disease; and inhibition of angiotensin converting enzyme, on the one hand can promote renin - vascular tension In angiotensin system, the ratio of angiotensin Ⅱ / angiotensin Ⅰ is decreased. On the other hand, the release of EDRF through the action of bradykinin plays a further beneficial role in cardiovascular diseases.