论文部分内容阅读
[目的]观察普罗布考治疗对早期糖尿病肾病尿微量白蛋白的影响。[方法]将106例2型糖尿病患者随机分为常规治疗组和普罗布考组,每组各53例。常规治疗组使用降压、降糖、调脂、抗血小板聚集等治疗措施,普罗布考组在常规药物治疗的基础上口服普罗布考片0.5 g,每日2次。两组治疗时间均为3个月。比较两组治疗前后血压、空腹血糖、三酰甘油、总胆固醇、低密度脂蛋白胆固醇、C-反应蛋白、纤维蛋白原水平和尿微量白蛋白变化。[结果]与治疗前比较,两组治疗后收缩压、血糖、血脂、尿微量白蛋白均明显下降(P<0.05);普罗布考组的尿微量白蛋白、C反应蛋白、纤维蛋白原水平较常规药物组有明显下降(P<0.05)。[结论]两组患者的血糖、血脂、血压水平组间差别无统计学意义(P>0.05);在常规药物治疗的基础上联合普罗布考,能有效降低尿微量白蛋白,对早期糖尿病肾病有治疗作用。
[Objective] To observe the effect of probucol treatment on urinary albumin in patients with early diabetic nephropathy. [Methods] 106 patients with type 2 diabetes were randomly divided into routine treatment group and probucol group, each group of 53 cases. The conventional treatment group used antihypertensive, hypoglycemic, lipid-lowering, anti-platelet aggregation and other treatment measures, probucol group on the basis of conventional drug therapy oral probucol 0.5 g tablets, 2 times a day. The two groups were treated for 3 months. Blood pressure, fasting blood glucose, triglyceride, total cholesterol, low density lipoprotein cholesterol, C-reactive protein, fibrinogen and urine microalbumin were compared before and after treatment. [Results] Compared with before treatment, systolic blood pressure, blood glucose, blood lipids and urine microalbumin were significantly decreased in both groups (P <0.05), and urine microalbumin, C-reactive protein and fibrinogen Compared with the conventional drug group was significantly decreased (P <0.05). [Conclusion] There was no significant difference between the two groups in the levels of blood glucose, blood lipids and blood pressure (P> 0.05). On the basis of routine drug therapy combined with probucol, it can effectively reduce the microalbuminuria and early diabetic nephropathy A therapeutic effect.