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为评价头孢替坦二钠的体外抗菌活性,本研究测定了其对663株临床分离菌的MIC分布,并与四种头孢菌素进行比较。结果表明,头孢替坦二钠对革兰阴性菌抗菌作用较强,对革兰阳性菌的抗菌作用较弱。在受试革兰阴性菌中,头孢替坦二钠对大肠埃希菌、肺炎克雷伯杆菌、奇异变形杆菌、阴沟肠杆菌等11种菌具有较强的抗菌活性,尤其对产ESBLs大肠埃希菌、肺炎克雷伯杆菌抗菌活性突出,MIC90分别为4、8μg/mL。在革兰阳性菌中,头孢替坦二钠对金黄色葡萄球菌、表皮葡萄球菌、化脓链球菌、肺炎链球菌具有一定抗菌活性,但对MRSA、MRSE、粪肠球菌、屎肠球菌的抗菌活性弱。
In order to evaluate the antibacterial activity of cefotetan disodium in vitro, this study determined the MIC distribution of 663 clinical isolates and compared them with four cephalosporins. The results showed that cefotetan disodium showed strong antibacterial activity against Gram-negative bacteria and weak antibacterial activity against Gram-positive bacteria. Cefotiam disodium has strong antibacterial activity on Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Enterobacter cloacae and other 11 kinds of bacteria in the tested Gram-negative bacteria, especially for ESBLs-producing large intestine Mycobacterium, Klebsiella pneumoniae antibacterial activity prominent, MIC90 were 4, 8μg / mL. In Gram-positive bacteria, cefotetan disodium has antibacterial activity against Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pyogenes and Streptococcus pneumoniae, but has antibacterial activity against MRSA, MRSE, Enterococcus faecalis and Enterococcus faecium weak.