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Gymnaster koraiensis是一种韩国特产的菊科植物。关于此种植物的化学成分和生物活性文献中尚无记载。作为化学和生物学活性评价的部分,作者分离出一些化合物,并评价了其抗增殖活性、一氧化氮生成抑制活性及其酰基辅酶A、胆固醇-酰基转移酶(ACAT)抑制作用。 生物学活性成分的分离:用加10％水后的二氯甲烷分离植物根的甲醇提取物。反复硅胶柱层析并制备二氯甲烷组分的HPLC,得到8个聚乙炔,根据物理化学和
Gymnaster koraiensis is a kind of asteraceae that is a special product of Korea. There is no record of the chemical composition and biological activity of this plant. As part of the evaluation of chemical and biological activity, the authors isolated a number of compounds and evaluated their anti-proliferative activity, nitric oxide production inhibitory activity and their acyl-CoA, cholesterol-acyltransferase (ACAT) inhibition. Separation of Biologically Active Ingredient: The methanol extract of plant roots was separated with dichloromethane after addition of 10% water. Repeated silica gel column chromatography and HPLC preparation of the dichloromethane component yielded 8 polyacetylenes, based on physical chemistry and