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为了评价抗结核药可能对遗传的损伤,作者选择55例初治结核病患者(分为3组,每组用1个治疗方案),观察3种短程化疗方案(2HSRZ、2HRZ 和2H_2R_2Z_2)对淋巴细胞姊妹染色单体交换(SCEs)的影响.结果2HSRZ 组(每日H 为300mg、R450mg、Z1.5g、S 0.75～1.0g)治疗前平均SCEs/细胞为6.95,治疗后为7.50,治疗后明显增加(P<0.05)2HRZ 组(各药用量同2HSRZ 组)治疗前平均SCEs/细胞为6.18,治疗后为7.73,治疗后明显增加.(P<0.05)。2H_2R_2Z_2组(H600mg、R900
In order to evaluate the possible genetic damage caused by anti-TB drugs, the authors selected 55 patients with untreated tuberculosis (divided into three groups with one treatment regimen) and observed the effects of three short-course chemotherapy regimens (2HSRZ, 2HRZ and 2H_2R_2Z_2) on lymphocytes Sisters chromatid exchange (SCEs) .Results The average SCEs / cells in 2HSRZ group (daily H 300mg, R450mg, Z 1.5g, S 0.75-1.0g) before treatment were 6.95 and 7.50 after treatment (P <0.05). The average SCEs / cell number before treatment in 2HRZ group was 6.18 and 7.73 after treatment, respectively, which was significantly increased after treatment (P <0.05). 2H_2R_2Z_2 group (H600mg, R900