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目的 :探讨血管内皮生长因子 (VEGF)和大肠癌发生发展的关系。方法 :免疫组化 L SAB法对 5 2例大肠癌组织、1 9例大肠腺瘤组织和 1 8例正常大肠粘膜组织的 VEGF表达进行研究。结果 :正常大肠粘膜组织 VEGF表达阴性 ,大肠腺瘤和大肠癌的 VEGF阳性率分别为 2 6 .32 %和 5 1 .92 % ,显著高于正常大肠粘膜 (P<0 .0 1 ) ;VEGF在有淋巴结转移的大肠癌组阳性率为 6 8.1 8% ,明显高于无淋巴转移组的 40 .0 0 % (P<0 .0 5 ) ;VEGF的阳性率随 Dukes分期增加 ,且 Dukes A期、Dukes B期和 Duke C期相比 ,差异显著 (P<0 .0 5 ) ,但与大肠癌的组织学类型、分化程度无关 (P>0 .0 5 )。结论 :VEGF促进了大肠癌的发生发展 ,可作为反映大肠癌生物学行为的指标之一。
Objective: To investigate the relationship between vascular endothelial growth factor (VEGF) and the occurrence and development of colorectal cancer. Methods: Immunohistochemical L SAB method was used to study the VEGF expression in 52 cases of colorectal carcinoma, 19 cases of colorectal adenoma and 18 cases of normal colorectal mucosa. Results: The VEGF expression in normal colorectal mucosa was negative. The positive rates of VEGF in colorectal adenoma and colorectal carcinoma were 26.32% and 51.92%, respectively, which were significantly higher than those in normal colorectal mucosa (P <0.01). VEGF The positive rate of colorectal cancer with lymph node metastasis was 6 8.18%, which was significantly higher than that of non-lymphatic metastasis 40.0% (P <0.05). The positive rate of VEGF increased with Dukes stage, and Dukes A There was significant difference between Dukes B and Dukes C (P <0.05), but not with histological type and differentiation (P> 0.05). Conclusion: VEGF can promote the development of colorectal cancer and can be used as one of the indicators of biological behavior of colorectal cancer.