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目的 :探索非增强磁共振成像(MRI)对微小或小肝癌的诊断价值和限制。材料和方法 :对诱发和接种肝肿瘤的21只和24只大鼠模型进行MR检查 ,并与病理进行对照。对诱癌肝结节和接种Walker -256癌肉瘤的数目、体积、形态、信号、信噪比和相对信噪比进行了分析测量和比较。结果 :MRT1 加权成像(T1WI)和T2 加权成像(T2WI)检出≥3mm诱癌结节的灵敏度分别为15.8 %和25.1 % ;检出≥5mm结节的灵敏度分别为77.4 %和94.3 %。T1WI检出最大诱癌肿块和Walker -256癌肉瘤体积显著小于T2WI(p 值分别<0.005和0.001) ,标本实测结果介于T1WI和T2WI之间 ,与T1WI更为接近。诱癌结节和癌肉瘤在T1WI上为低信号 ;T2WI上除直径5mm以上的诱癌结节出现混杂信号外 ,多为均匀高信号。结论 :MRI显示5mm以下的肝结节的灵敏度较低 ,对≥5mm的结节灵敏度显著提高 ;T1WI对肿瘤大小的判断较准确。
Objective: To explore the diagnostic value and limitation of non-enhanced magnetic resonance imaging (MRI) for small or small hepatocellular carcinoma. MATERIALS AND METHODS: Twenty-one and twenty-four rat models of induced and vaccinated liver tumors were examined by MR and compared with pathology. The number, volume, morphology, signal, signal-to-noise ratio and relative signal-to-noise ratio of induced cancer nodules and inoculated Walker-256 carcinoma sarcoma were measured and compared. Results: The sensitivities of cancerous nodules with ≥3mm were detected by MRT1 weighted imaging (T1WI) and T2 weighted imaging (T2WI) were 15.8% and 25.1% respectively. The sensitivity of detecting ≥5mm nodules were 77.4% and 94.3% respectively. T1WI detected the largest tumor-inducing mass and Walker-256 carcinosarcoma volume was significantly less than T2WI (p values were <0.005 and 0.001, respectively), the measured results between the T1WI and T2WI, and T1WI closer. Tumorigenic nodules and carcinosarcoma in the T1WI is a low signal; T2WI in addition to 5mm diameter above the cancer-inducing nodules appear mixed signal, mostly uniform high signal. Conclusion: MRI showed that the sensitivity of hepatic nodules less than 5mm was lower, and the sensitivity of nodules≥5mm was significantly improved. The judgment of tumor size by T1WI was more accurate.