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用人乙肝病毒（ＨＢＶ）接种树的，建立ＨＢＶ感染动物模型，实现连续传代感染，并用乙肝疫苗预防其感染。以此模型研究ＨＢＶ及（或）黄曲霉毒素Ｂ１（ＡＦＢ１）在诱发肝癌中的作用。结果肝癌诱发率在同时接受两种因子者显著高于单一因子者，癌前病变的发生与肝癌诱发率相关，被感染树的肝组织及（或）肝癌中检出ＨＢＶＤＮＡ可整合于宿主肝ＤＮＡ。提示ＨＢＶ和ＡＦＢ１起协同致癌作用并支持ＨＢＶ与肝癌的病因学关系。
Inoculation of human hepatitis B virus (HBV) in the tree, the establishment of animal models of HBV infection, to achieve continuous passage of infection, and hepatitis B vaccine to prevent its infection. This model was used to investigate the role of HBV and / or aflatoxin B1 (AFB1) in the induction of hepatocellular carcinoma. Results The induction rate of HCC was significantly higher than that of single factor in both of the two factors. The occurrence of precancerous lesions was related to the induction rate of HCC. The detection of HBVDNA in the infected liver tissue and / or liver cancer could be integrated into the host liver DNA . Suggesting that HBV and AFB1 have a synergistic carcinogenic effect and support the etiological relationship between HBV and hepatocellular carcinoma.