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目的:探讨胺碘酮静脉给药治疗心房纤维颤动患者引起休克的临床特点。方法:收集2003年至2007年中文医学文献关于胺碘酮静脉给药治疗心房纤维颤动患者引致休克的临床资料,包括患者的基础心脏病,心房纤维颤动发作时的心律、心率、血压、心功能状态、心电图以及胺碘酮的用法用量。对胺碘酮输液的浓度、静脉滴注速度和总剂量以及休克发生的时间、表现和处理进行分析。结果:共收集7例胺碘酮所致休克患者的临床资料,其中2例来自本院。胺碘酮溶于5%葡萄糖注射液100ml中,浓度为1.5～7.5mg/ml,静脉给药速度为2.5～10mg/min。用药后休克发生的时间,4例为2min内,3例为5～20min内,持续时间为3～120min。2例休克患者伴有意识障碍,5例患者休克时仍有心房纤维颤动。结论:胺碘酮静脉给药可能引起休克,临床表现危重,及时对症治疗可缓解。
Objective: To investigate the clinical characteristics of intravenous amiodarone in patients with atrial fibrillation induced by shock. METHODS: We collected data from 2003 to 2007 on intravenous amiodarone in patients with atrial fibrillation induced by intravenous amiodarone, including patients with underlying heart disease, heart rhythm at onset of atrial fibrillation, heart rate, blood pressure, heart function Status, ECG and Amiodarone Usage and dosage. Amiodarone infusion concentration, intravenous infusion rate and total dose and shock time, performance and treatment were analyzed. Results: A total of 7 cases of amiodarone-induced shock in patients with clinical data, of which 2 cases from our hospital. Amiodarone dissolved in 5% glucose injection 100ml, the concentration of 1.5 ~ 7.5mg / ml, intravenous infusion rate of 2.5 ~ 10mg / min. Shock occurred after treatment time, 4 cases for 2min, 3 cases for 5 ~ 20min, the duration of 3 ~ 120min. Two patients with shock were associated with disturbance of consciousness and five patients had atrial fibrillation during shock. Conclusion: Amiodarone intravenous administration may cause shock, clinical manifestations of critical, timely symptomatic treatment can be alleviated.