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用亲水性、高比表面积、硅烷化硅小球担载钯 ,以 (S) -脯氨酸为手性助剂、苯乙酮为反应底物 ,考察不对称加氢反应和不同有机碱助催化剂的影响 .实验表明 ,当使用三辛胺助催化剂时 ,(R) -苯乙醇的对映异构体选择性可达 1 7.5% .将 (S) -脯氨酸负载于亲水性、高比表面积、硅烷化硅小球担体表面 ,以 Pd(OAc) 2 为催化剂前体 ,制备负载型手性固相催化剂 ,初步考察了 (S) -脯氨酸与中心金属钯的摩尔比、疏水性不同的有机溶剂和有机碱助催化剂对不对称加氢反应的影响 ,以及该催化剂的循环使用情况 .结果表明 ,以 2 - (1 -环己烯基乙基胺为助催化剂 ,(R) -苯乙醇的立体选择性最高达到 1 2 .4%
Hydrophilic, high surface area, silanized silica beads loaded with palladium, (S) - proline as a chiral auxiliary, acetophenone as the reaction substrate, investigated the asymmetric hydrogenation reaction and different organic bases The experiment showed that the enantioselectivity of (R) -phenylethanol reached as high as 15.5% when trioctylamine was used as cocatalyst, and (S) -proline was supported on hydrophilic , High specific surface area, the surface of silanized silica bead support and Pd (OAc) 2 as catalyst precursor to prepare supported chiral solid phase catalysts. The molar ratio of (S) - proline to central metal palladium , The effects of different hydrophobic organic solvents and organic cocatalysts on the asymmetric hydrogenation and the recycling of these catalysts were investigated.The results showed that the catalyst was successfully prepared by using 2 - (1 - cyclohexenylethylamine as cocatalyst, ( R) -phenethyl alcohol stereoselectivity up to 12.4%