论文部分内容阅读
目的:探讨急性前壁心肌梗死患者急诊经皮冠脉介入治疗(PCI)早期应用替罗非班的疗效及安全性。方法:将2009年8月至2012年12月佛山市第二人民医院收治的188例急性前壁心肌梗死拟行急诊PCI患者随机分为观察组(早期应用组,92例)和对照组(延迟应用组,96例),比较两组PCI TIMI血流分级、血BNP、CTnI水平变化及主要不良心血管事件和出血风险等。结果:观察组初次造影病变血管TIMI血流达到Ⅲ级的比率明显高于延迟应用组(P<0.05);术后7 d血CTnI、BNP水平明显低于对照组(P<0.05);30 d不良心血管事件发生率低于对照组(P<0.05)。结论:急性前壁心肌梗死患者急诊PCI早期应用替罗非班有助于改善心肌灌注,降低早期不良心血管事件,可能有助于改善远期预后。
Objective: To investigate the efficacy and safety of early application of tirofiban in emergency percutaneous coronary intervention (PCI) in patients with acute anterior myocardial infarction. Methods: A total of 188 patients with acute anterior myocardial infarction who underwent emergency PCI admitted to Second People’s Hospital of Foshan from August 2009 to December 2012 were randomly divided into observation group (92 cases in early application group) and control group (delayed Application group, 96 cases). The PCI TIMI grade, blood BNP, CTnI level changes and major adverse cardiovascular events and bleeding risk were compared between the two groups. Results: The ratio of TIMI blood flow to grade Ⅲ in the primary angiography lesion in the observation group was significantly higher than that in the delayed application group (P <0.05). The levels of CTnI and BNP in the blood at 7 d after operation were significantly lower than those in the control group (P <0.05) The incidence of adverse cardiovascular events was lower than that of the control group (P <0.05). Conclusion: Early application of tirofiban in patients with acute anterior myocardial infarction may improve myocardial perfusion and reduce early adverse cardiovascular events, which may be helpful to improve long-term prognosis.