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目的了解沈阳市2015年部分新发现HIV/AIDS患者首次CD4~+T淋巴细胞检测结果,了解患者机体免疫功能变化,为AIDS抗病毒治疗提供依据。方法筛选2015年在3个月内确证HIV抗体阳性的HIV/AIDS患者110例,经流行病学调查后采集静脉血,用流式细胞仪检测淋巴细胞亚群相对和绝对数量,并对检测数据进行分析。结果 HIV/AIDS患者首次检测的CD4~+T淋巴细胞均值456±232个/μL,其中<200个/μL 18例(16.4%),200~349个/μL 17例(15.5%),350~499个/μL 27例(24.6%);CD4~+≥500个/μL 48例(43.6%)。结论我市HIV感染者发现较早,首次检测CD4~+T淋巴细胞数量较高,免疫功能损伤程度较低。早发现、早治疗是防治AIDS的重要措施,早期发现感染者、及时随访及首次CD4~+T淋巴细胞检测,对把握治疗时机,延缓AIDS进展,提高病人生存质量有重要意义。
Objective To understand the results of the first CD4 ~ + T lymphocyte test in some newly discovered HIV / AIDS patients in Shenyang in 2015, and to understand the changes of immune function in patients with AIDS. Methods A total of 110 HIV / AIDS-positive HIV-positive patients were screened in 3 months in 2015. Venous blood was collected after epidemiological investigation. The relative and absolute numbers of lymphocyte subsets were detected by flow cytometry. The detection data Analyze. Results The mean CD4 ~ + T lymphocytes in HIV / AIDS patients were 456 ± 232 / μL for the first time, of which 18 cases (16.4%) were less than 200 cells / μL, 17 cases (15.5%) were 200 ~ 349 cells / μL, 499 / μL in 27 cases (24.6%); CD4 ~ + ≥500 / μL in 48 cases (43.6%). Conclusion HIV-infected people in our city were found earlier, the number of CD4 ~ + T lymphocytes detected for the first time was higher, and the degree of immune dysfunction was lower. Early detection and early treatment are important measures to prevent and treat AIDS. Early detection of infected persons, timely follow-up and the first detection of CD4 ~ + T lymphocytes are important for grasping the timing of treatment, delaying the progress of AIDS and improving the quality of life of patients.