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目的 为阐明乳腺癌组织中PTEN蛋白表达改变的意义。方法 利用SP免疫组化技术检测PTEN蛋白在乳腺癌、不典型导管内上皮增生、正常乳腺组织的表达。结果 乳腺癌PTEN蛋白的阳性率和阳性强度低于正常乳腺 (P <0 0 1)和不典型导管内上皮增生组 (P <0 0 5 ) ;表达强度与乳腺癌分化程度有关 (P <0 0 5 ) ,分化愈差 ,表达愈弱。不典型导管内上皮增生PTEN的表达比正常乳腺低 (P <0 0 5 ) ,较乳腺癌组织强 (P <0 0 5 )。结论 通过检测PTEN的表达 ,对估计乳腺癌的预后有一定意义 ,可预测不典型导管内上皮增生发生癌变的可能性
Objective To clarify the significance of PTEN protein expression in breast cancer. Methods SP immunohistochemistry was used to detect the expression of PTEN protein in breast cancer, atypical ductal epithelial hyperplasia and normal breast tissue. Results The positive rate and positive rate of PTEN protein in breast cancer were lower than those in normal breast (P <0.01) and in atypical ductal epithelial hyperplasia (P <0 05). The expression of PTEN protein was correlated with the degree of breast cancer differentiation (P <0 0 5), the worse the differentiation, the weaker the expression. The expression of PTEN in atypical ductal epithelial hyperplasia was lower than that in normal breast (P <0 05) and stronger than that in breast cancer (P 0 05). Conclusions The detection of PTEN expression has some significance in estimating the prognosis of breast cancer and predicts the possibility of carcinogenesis of atypical ductal epithelial hyperplasia