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目的分析胎儿水肿的超声图像特征及产前超声诊断胎儿水肿的临床价值。方法回顾性分析2009年10月至2012年10月在本院经引产证实的41例胎儿水肿患儿的临床资料。检测孕产妇居住环境中的乙酸异戊酯浓度,并探讨乙酸异戊酯浓度与胎儿畸形的相关性。结果胎儿水肿综合征的超声图像具有特征性,表现为:皮肤水肿、胎儿胸腹水、胎盘增厚、肝大、肢体短小、羊水增多或减少等。超声诊断与临床诊断符合率达100%。回顾性分析发现,孕产妇居住环境空气中乙酸异戊酯浓度与胎儿畸形具有明显的相关性(P<0.05),差异有统计学意义。结论孕产妇居住和工作环境的乙酸异戊酯浓度与胎儿畸形具有明显的相关性,如果患者能按医嘱定期B超检查,可早期发现及时引产,减少围产儿死亡,此外应指导辖区育龄期妇女在怀孕前后远离乙酸异戊酯等污染物,以降低出生缺陷。
Objective To analyze the characteristics of fetal edema and the clinical value of prenatal diagnosis of fetal edema. Methods The clinical data of 41 cases of fetal edema confirmed by induction of labor in our hospital from October 2009 to October 2012 were retrospectively analyzed. The concentration of isoamyl acetate in maternal living environment was detected and the correlation between isopentyl acetate concentration and fetal malformation was also investigated. Results Ultrasound images of fetal edema syndrome were characterized by skin edema, fetal pleural fluid, placental thickening, liver enlargement, short limbs, increased or decreased amniotic fluid. Ultrasound diagnosis and clinical diagnosis in line with the rate of 100%. Retrospective analysis found that the concentration of isoamyl acetate in the air of maternal living environment was significantly correlated with fetal malformation (P <0.05), the difference was statistically significant. Conclusions The isoamyl acetate concentration in maternal living and working environment is significantly correlated with fetal malformations. If the patient can get regular B-ultrasound according to doctor’s orders, early detection of induced labor can reduce the risk of perinatal death. In addition, women of childbearing age should be instructed Stay away from isoamyl acetate and other contaminants before and after pregnancy to reduce birth defects.