论文部分内容阅读
目的:探讨胰腺实性假乳头状肿瘤(solid-pseudo-papillary tumor of pancreas,SPTP)的临床病理形态特征及免疫表型。方法:对5例SPTP患者的临床病理资料进行回顾性复习,并采用免疫组化SP法检测肿瘤细胞Vi m、NSE、a-AT、s-100、ck、EMA、syn、CgA抗体的表达。结果:5例SPTP患者中,因腹部不适或腹部疼痛来医院就诊时发现2例,3例为常规体检时发现,女性4例,男性1例,平均年龄36岁,肿瘤位于胰头3例,胰尾2例,瘤体平均大小为8.7cm,镜下肿瘤细胞主要排列成实性片状及假乳头状结构,细胞无明显异型性,5例SPTP患者中1例为老年男性,镜下大部分肿瘤细胞胞浆透明,有的呈印戒样改变,形态较为特别,免疫组化显示,5例Vi m、NSE呈弥漫强阳性,4例a-AT呈小灶性阳性,2例ck呈弱阳性,1例syn灶性阳性,s-100、EMA、CgA均为阴性。结论:胰腺实性假乳头状肿瘤(SPTP)好发于年青女性,镜下瘤细胞主要排列成实性片状及假乳头状结构,是一种具有低度恶性潜能的病变,组织形态学特征和免疫组化对其诊断及鉴别诊断具有重要价值。
Objective: To investigate the clinicopathological features and immunophenotype of solid-pseudo- papillary tumor of pancreas (SPTP). Methods: The clinicopathological data of 5 SPTP patients were retrospectively reviewed. The expression of Vi m, NSE, a-AT, s-100, ck, EMA, syn and CgA in tumor cells were detected by immunohistochemical SP method. Results: In 5 cases of SPTP patients, 2 cases were found in the hospital due to abdominal discomfort or abdominal pain. In 3 cases, there were 4 cases of female and 4 cases of male, mean age was 36 years. The tumor was located in the pancreas in 3 cases, The tail of the tail was 2 and the average size of the tumor was 8.7 cm. The tumor cells were mainly arranged in the form of solid lamellar and pseudopapillary structures without obvious atypia. One of 5 SPTP patients was an elderly male, Some of the tumor cells were cytoplasm transparent, and some of them showed signet ring-like changes. The immunohistochemistry showed that 5 cases of Vi m and NSE were diffuse and strongly positive, 4 cases of a-AT were small focal and 2 cases of ck were weak Positive, 1 case of syn focal positive, s-100, EMA, CgA were negative. CONCLUSIONS: The solid pseudopapillary tumors (SPTP) of the pancreas occur in young women. The microscopic tumor cells are mainly arranged in the form of solid lamellar and pseudopapillary structures. They are a kind of lesion with low malignant potential and histological features And immunohistochemistry for its diagnosis and differential diagnosis of great value.