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原发性肾病综合征(primary nephrotic syndrome,PNS)发病机制尚不清楚,多数学者认为与机体免疫功能紊乱有关。研究已证实PNS患儿血液循环中免疫细胞及细胞因子可以直接或间接引起肾小球损伤,肿瘤坏死因子(tumor necrosis factor,TNF)是与肾小球损伤密切相关的细胞因子之一。我们观测了PNS不同临床分期血清TNF的动态变化,并与其它生化指标进行了相关分析。目的是深入探讨TNF与PNS的发生和发展的关系,为PNS的诊断和治疗提供理论依据。
The pathogenesis of primary nephrotic syndrome (PNS) remains unclear, and most scholars believe it is related to immune dysfunction. Studies have confirmed that immune cells and cytokines in the blood circulation of PNS children can cause glomerular injury directly or indirectly. Tumor necrosis factor (TNF) is one of the cytokines closely related to glomerular injury. We observed the dynamic changes of serum TNF levels in different clinical stages of PNS, and correlated with other biochemical parameters. The aim is to explore in depth the relationship between the occurrence and development of TNF and PNS and provide a theoretical basis for the diagnosis and treatment of PNS.