目的　总结耐甲氧西林金黄色葡萄球菌 (MRSA)院内肺部感染的特点及万古霉素的疗效。方法　分析 4年来确诊为MRSA院内肺部感染 6 9例 ,研究其相关易感因素、药敏试验、抗生素使用情况和治疗效果。结果　 6 9例均存在严重基础疾患、人工气道、机械通气、抗生素的滥用和免疫功能低下等因素。MRSA对万古霉素 10 0 %敏感 ,三甲磺胺和利福平敏感率较高 ,其余抗生素敏感率极低。万古霉素治疗效果好。结论　MR SA院内肺部感染者均存在明确易感因素。万古霉素为首选的治疗药物 Objective To summarize the characteristics of nosocomial pulmonary infection in methicillin-resistant Staphylococcus aureus (MRSA) and the efficacy of vancomycin. Methods Sixty-nine cases of pulmonary infection in the hospital for MRSA were analyzed in the past four years. The related susceptibility factors, susceptibility testing, antibiotic use and therapeutic effect were studied. Results All 69 patients had severe underlying diseases, artificial airway, mechanical ventilation, antibiotic abuse and immunocompromise. MRSA is 100% sensitive to vancomycin, with higher sensitivity to trimethoprim and rifampicin, with minimal sensitivity to the remaining antibiotics. Vancomycin treatment is effective. Conclusions There are definite and susceptible factors in pulmonary infection in MR SA hospital. Vancomycin is the treatment of choice