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目的 寻找治疗CHB、抗纤维化的有效方法。方法 12 1例CHB病人随机分为联合组和单独组 ,联合组 66例给予甘草酸二铵 15 0mg ,注射用促肝细胞生长素 12 0mg ,分别加入 10 %葡萄糖注射液 2 5 0ml中每天静滴 1次 ,3 0d为 1个疗程。单独组 5 5例只用甘利欣注射液 15 0mg加入 10 %葡萄糖 2 5 0ml中静滴 ,每天 1次。两组除口服维生素外 ,不用其他药物 ,主要观察治疗前后血清谷丙转氨酶 (ALT)、总胆红素(TBIL)、白蛋白 /球蛋白 (A/G)、血清Ⅲ型前胶原 (PCⅢ )、层连蛋白 (LN)、透明质酸 (HA)等指标变化。结果 联合组症状改善明显 ,ALT、TBIL下降明显 ,A/G升高显著 ,血清纤维化指标下降显著。结论 甘草酸二铵联合注射用促肝细胞生长素可有效保护肝细胞 ,改善肝功能 ,减轻肝细胞的炎症反应 ,抑制肝纤维化的发展
Objective To find an effective method to treat CHB and prevent fibrosis. Methods One hundred and twenty CHB patients were randomly divided into combined group and single group. 66 cases in combination group were given diammonium glycyrrhizinate 150 mg and injected hepatocyte growth-promoting factor 120 mg respectively, and were added to 250 ml of 10% glucose injection daily Drop 1, 3 0d for a course of treatment. Fifty-five patients in the separate group were intravenously dripped with 250ml of Glycyrrhizin alone in 250ml of 10% glucose once daily. The two groups except oral vitamin, without other drugs, the main observation before and after treatment of serum alanine aminotransferase (ALT), total bilirubin (TBIL), albumin / globulin (A / G), serum type Ⅲ procollagen (PC Ⅲ) , Laminin (LN), hyaluronic acid (HA) and other indicators change. Results The symptoms of the combination group improved obviously, ALT, TBIL decreased significantly, A / G increased significantly, serum fibrosis index decreased significantly. Conclusions Combination of glycyrrhizic acid diammonium and hepcidin for injection can effectively protect hepatocytes, improve liver function, reduce the inflammatory response of hepatocytes and inhibit the development of hepatic fibrosis