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目的:比较抗菌药应用干预前后的情况,探索实施抗菌药合理使用方案的可行性。方法:通过制定规范、加强教育、分级管理、检查反馈等措施来干预临床抗菌药不合理使用的现象。对医院干预前(2009年)和干预后(2010年)门诊及住院患者的抗菌药使用情况进行统计。结果:干预后门诊处方抗菌药使用比例由38.26%下降至21.36%,住院患者抗菌药使用比例由70.31%下降至51.87%,无指征用药由4.92%下降至2.50%,Ⅰ类切口患者术后平均预防用药时间缩短了2.1 d,差异均有统计学意义(P<0.05)。结论:干预措施对促进医院抗菌药的合理使用是可行和有效的。
Objective: To compare the situation before and after the application of antibacterials, and to explore the feasibility of the rational use of antibacterials. Methods: Through the formulation of norms, strengthening education, management at different levels, check the feedback and other measures to intervene the phenomenon of clinical use of antimicrobial agents unreasonable. Statistics on the use of antibacterials in outpatients and inpatients before (2009) and after (2010) hospital interventions were collected. Results: After the intervention, the proportion of prescription antibacterials used in outpatient clinics decreased from 38.26% to 21.36%, the percentage of antibacterials in inpatients decreased from 70.31% to 51.87%, and the rate of non-indicted drugs decreased from 4.92% to 2.50% The average preventive medication time was shortened by 2.1 days, the differences were statistically significant (P <0.05). Conclusion: Interventions are feasible and effective to promote the rational use of antimicrobial agents in hospitals.