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1例75岁男性患者因房室传导阻滞行永久起搏器植入术,术后出现感染性心内膜炎。首先单独给予头孢哌酮钠-舒巴坦钠3.0 g1、次/12 h静脉滴注4 d,然后改为万古霉素1.0 g1、次/12 h静脉滴注3 d,最后单独应用利奈唑胺600 mg1,次/12 h静脉滴注44 d。应用利奈唑胺前实验室检查示患者外周血白细胞12.00×109/L,红细胞3.92×1012/L,血小板158×109/L,血红蛋白115 g/L。用药第19天血常规示白细胞2.81×109/L,红细胞3.39×1012/L,血小板74×109/L,血红蛋白102 g/L。其后血常规检查显示各项指标均低于正常范围,最低值如下:白细胞2.69×109/L,红细胞2.51×1012/L,血小板48×109/L,血红蛋白69 g/L。由于病情需要未停用利奈唑胺,给予重组人粒细胞集落刺激因子、琥珀酸亚铁及红细胞悬液等对症治疗。患者应用利奈唑胺共44 d。停药后18 d血常规恢复正常:白细胞5.07×109/L,红细胞3.02×1012/L,血小板156×109/L,血红蛋白102 g/L。
A 75-year-old male patient underwent permanent pacemaker implantation due to atrioventricular block. Infective endocarditis occurred postoperatively. Cefoperazone sodium-sulbactam sodium 3.0 g1 was given first, once every 12 hours for 4 days, then vancomycin 1.0 g1, once every 12 hours for 3 days, then linezolid 600 mg 1 was given alone, Times / 12 h intravenous infusion 44 d. Linezolid pre-laboratory tests showed that patients with peripheral blood leukocytes 12.00 × 109 / L, erythrocyte 3.92 × 1012 / L, platelet 158 × 109 / L, hemoglobin 115 g / L. On the 19th day, the blood samples showed leukocyte 2.81 × 109 / L, erythrocyte 3.39 × 1012 / L, platelet 74 × 109 / L and hemoglobin 102 g / L. Subsequent blood tests showed that the indicators were below the normal range, the minimum values are as follows: leukocyte 2.69 × 109 / L, red blood cells 2.51 × 1012 / L, platelet 48 × 109 / L, hemoglobin 69 g / L. Because of the condition need to be disabled linezolid, given recombinant human granulocyte colony stimulating factor, ferrous succinate and erythrocyte suspension symptomatic treatment. Linezolid was administered for 44 days. Blood routine returned to normal 18 days after drug withdrawal: leukocyte 5.07 × 109 / L, erythrocyte 3.02 × 1012 / L, platelet 156 × 109 / L and hemoglobin 102 g / L.