论文部分内容阅读
目的:探讨高血压脑出血患者服用尼莫地平片对神经功能与血清炎性因子的影响.方法:回顾性选取新疆医科大学第二附属医院2014-05/2015-11接诊的134例高血压脑出血患者作为研究对象,依据不同的治疗方式,将仅给予基础止血、降压、消炎等治疗的患者列为基础治疗组(n=67),将基于基础治疗,加用尼莫地平的患者列为研究治疗组(n=67).观察两组患者血清炎性因子、神经功能与副反应情况.结果:研究治疗组血清炎性因子水平、神经功能缺损评分(NIHSS)的改善幅度均明显高于基础治疗组,差异具有统计学意义(P<0.05).治疗期间,研究治疗组副反应发生率为11.94%,基础治疗组副反应发生率为4.48%,研究治疗组副反应症状较基础治疗组明显,差异具有统计学意义(P<0.05).结论:尼莫地平能够明显改善高血压脑出血患者的神经功能缺损程度,其机制可能与调节血清炎性因子TNF-α、IL-1β、hs-CRP有关.
Objective: To investigate the effects of nimodipine tablets on neurological function and serum inflammatory factors in patients with hypertensive intracerebral hemorrhage.Methods: A retrospective study was conducted to select 134 hypertension patients admitted to the Second Affiliated Hospital of Xinjiang Medical University from May 2014 to November 2015 Patients with cerebral hemorrhage as the research object, according to different treatment methods, will be given only basic hemostasis, antihypertensive, anti-inflammatory treatment of patients as the basic treatment group (n = 67), will be based on the basic treatment, add nimodipine patients (N = 67) .Serum inflammatory factors, neurological function and side effects were observed.Results: The levels of serum inflammatory cytokines and neurological deficit scores (NIHSS) in treatment group were significantly improved (P <0.05) .In the treatment period, the incidence of side effects was 11.94% in the study group and 4.48% in the basic group, and the incidence of side effects in the study group was more than that in the basic group (P <0.05) .Conclusion: Nimodipine can significantly improve the degree of neurological deficit in patients with hypertensive intracerebral hemorrhage, the mechanism may be related to the regulation of serum inflammatory cytokines TNF-α, IL-1β , Hs -CRP related.