Objectives: In this prospective study, we investigated the prevalence and characteristics of clearly discernible noncalcified coronary plaques in a patient population with suspected significant coronary artery disease(CAD) by using 64-slice computed tomography(CT). Background: The assessment of noncalcified coronary plaques by noninvasive strategies may be important to improve cardiovascular risk stratification. Methods: To rule out significant stenosis, high-resolution 64-slice coronary CT(0.6-mm collimation, 330-ms gantry rotation time) was performed in 161 consecutive patients with an intermediate risk for having CAD. Computed tomography data sets were evaluated for presence of coronary calcifications, noncalcified plaques, and/or lumen narrowing. Results: Noncalcified coronary plaques were detected in 48(29.8%) of 161 enrolled patients. Although noncalcified plaques together with coronary calcifications were present in 38 of 161(23.6%) patients, the prevalence of noncalcified plaques as the only manifestation of CAD was 6.2%(10 of 161 patients). Patients with noncalcified plaques were characterized by significantly higher total cholesterol, low-density lipoprotein, and C-reactive protein levels as well as a trend for more diabetes mellitus. The majority of noncalcified plaques resulted in lumen narrowing of< 50%. Of the remaining 113 patients, CAD and coronary calcifications were ruled out in 53 of 161(32.9%) patients, whereas 60 of 161(37.3%) patients presented with calcifications in the absence of noncalcified plaque. Conclusions: With the use of 64-slice CT, clearly discernible noncalcified atherosclerotic coronary plaques can be detected in a large group of patients with an intermediate risk for having CAD. The assessment of these plaques by CT angiography may allow for improved cardiovascular risk stratification. Objectives: In this prospective study, we investigated the prevalence and characteristics of clearly discernible noncalcified coronary plaques in a patient population with suspected significant coronary artery disease (CAD) by using 64-slice computed tomography (CT). Background: The assessment of noncalcified coronary plaques by noninvasive strategies may be important to improve cardiovascular risk stratification. Methods: To rule out significant stenosis, high-resolution 64-slice coronary CT (0.6-mm collimation, 330-ms gantry rotation time) was performed in 161 consecutive patients with an Intermediate risk for having CAD. Computed tomography data sets were evaluated for presence of coronary calcifications, noncalcified plaques, and / or lumen narrowing. Results: Noncalcified coronary plaques were detected in 48 (29.8%) of 161 enrolled patients. coronary calcifications were present in 38 of 161 (23.6%) patients, the prevalence of noncalcified plaqu es as the only manifestation of CAD was 6.2% (10 of 161 patients). Patients with noncalcified plaques were characterized by significantly higher total cholesterol, low-density lipoprotein, and C-reactive protein levels as well as a trend for more diabetes mellitus. The majority of noncalcified plaques resulted in lumen narrowing of <50%. Of the remaining 113 patients, CAD and coronary calcifications were ruled out in 53 of 161 (32.9%) patients, while 60 of 161 (37.3%) patients presented with calcifications in The absence of noncalcified plaque. Conclusions: With the use of 64-slice CT, clearly discernible noncalcified atherosclerotic coronary plaques can be detected in a large group of patients with an intermediate risk for having CAD. The assessment of these plaques by CT angiography may allow for improved cardiovascular risk stratification.