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报道该院肝胆外科与瑞典Lund大学合作的一项临床前瞻性研究。作者将1994年2月至1995年4月期间入院的40例经手术及病理证实为不可切除的肝细胞型肝癌(HCC)患者随机分成二组,重复暂时性去肝动脉化(RTD组)及肝动脉结扎(HAL组)各20例;对二组病人的术后过程、肝功能变化、影象学检查、生存期、存活率等进行比较。结果表明:RTD组均优于HAL组,RTD组有效率70%,术后中位生存期8.2个月,术后6个月存活率79.7%;而HAL组有效率仅5%,术后中位生存期5.1个月,术后6个月存活率35.8%。文内详细介绍RTD的实施方法、病人对治疗的反应及处理,认为RTD具有缺血、防止侧支循环建立和派生氧自由基三重作用,疗效明显优于HAL,是一种有前景的肝癌外科缺血疗法,值得进一步的研究、推广和应用。
A clinical prospective study of hepatobiliary surgery in the hospital and Lund University in Sweden was reported. The authors randomly assigned 40 patients with unresectable hepatocellular carcinoma (HCC) who had undergone surgery and pathology from February 1994 to April 1995 to be randomly divided into two groups to repeat temporary dearterialization (RTD) and Twenty patients in each group received hepatic artery ligation (HAL group); postoperative course, liver function changes, imaging examination, survival time, and survival rate of the two groups were compared. The results showed that the RTD group was superior to the HAL group, the RTD group had an effective rate of 70%, the median postoperative survival period was 8.2 months, and the survival rate was 79.7% at 6 months postoperatively; while the HAL group had only 5% efficiency. The median postoperative survival time was 5.1 months, and the survival rate was 35.8% after 6 months. The article describes in detail the implementation of RTD, patient response to treatment and treatment, that RTD has ischemia, to prevent the establishment of collateral circulation and derived oxygen free radical triple effect, the effect is significantly better than HAL, is a promising surgical liver cancer Ischemic therapy deserves further research, promotion and application.