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目的 探讨血清标志物CEA ,CA2 42 在大肠癌的表达水平和诊断价值以及二种标志物的相关性。方法 应用放射免疫及免疫放射法检测 76例大肠癌病人血清中CEA ,CA2 42 。结果 二种标志物与大肠癌癌瘤部位不相关 ,CEA ,CA2 42 的阳性率分别为 5 6.5 8% ,5 9.2 1%。CEA在DukesA ,DukesB ,DukesC及DukesD的阳性率分别为 18.75 % ,42 .86% ,68.18%及 94.12 %。CA2 42 在DukesA ,DukesB ,DukesC及DukesD的阳性率分别为 3 7.5 0 % ,47.62 % ,68.18%及 82 .3 5 %。而二种标志物中有一种出现阳性则分别提高到 43 .75 % ,71.43 % ,86.3 6%及 10 0 %。且二种标志物血清水平随Dukes分期的升高而升高 ,各期均有统计学意义。CEA ,CA2 42 在DukesA ,DukesB ,DukesC及DukesD期的相关系数分别为 0 .78,0 .5 4,0 .5 0及 0 .85。结论 CA2 42 是一种与CEA不相互依赖的 ,适用于大肠癌诊断 ,治疗及预后判断的新的肿瘤标志物。联合检测血清标志物CEA ,CA2 42 可提高大肠癌诊断的阳性率 ,同时对大肠癌的治疗 ,预后的判断给予有力的依据。
Objective To investigate the expression and diagnostic value of serum markers CEA and CA2 42 in colorectal cancer and the correlation between the two markers. Methods Serum CEA and CA2 42 in 76 patients with colorectal cancer were detected by radioimmunoassay and radioimmunoassay. Results The two markers were not related to the location of colorectal cancer. The positive rates of CEA and CA2 42 were 5 6.5 8% and 5 9.21% respectively. The positive rates of CEA in DukesA, DukesB, DukesC and DukesD were 18.75%, 42.86%, 68.18% and 94.12%, respectively. The positive rates of CA2 42 in DukesA, DukesB, DukesC and DukesD were 37.5%, 47.62%, 68.18% and 82.35%, respectively. However, one of the two markers increased to 43.75%, 71.43%, 86.3% and 100% respectively. The serum levels of the two markers increased with the increase of Dukes staging, all stages were statistically significant. The correlation coefficients of CEA and CA2 42 in Dukes A, Dukes B, Dukes C and Dukes D were 0.78, 0.54, 0.55 and 0.85, respectively. Conclusion CA2 42 is a new tumor marker that is not interdependent with CEA and is suitable for diagnosis, treatment and prognosis of colorectal cancer. Joint detection of serum markers CEA, CA2 42 can increase the positive rate of diagnosis of colorectal cancer, while the treatment of colorectal cancer, to provide a strong basis for the prognosis.