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纳络酮为纯粹的吗啡拮抗药,临床主要用于治疗吗啡急性中毒.近年发现又有新用途.脊髓损伤脊髓损伤后可释出内啡肽使自动调节丧失,从而引起局部血流降低.纳络酮可阻断内啡肽的这神病理生理反应,增加局部血流,减轻脊髓损伤.Faden等的实验证实该药于脊髓损伤早期(伤后1h)和后期(伤后4h)均有治疗作用.功能恢复均比时照组明显.休克Peters等给11例(经用传统抗休克疗法无效的败血症性低血压)成人患者静注纳络酮,其中未接受皮质激素的8例.
Naloxone is a pure morphine antagonist, clinical mainly used for the treatment of acute morphine poisoning. In recent years found that there are new uses. Spinal cord injury after spinal cord injury can release endorphin loss of autonomic regulation, causing local blood flow decreased. Luokong can block this neuropathic physiologic reaction of endorphins, increase local blood flow and relieve spinal cord injury .Faden et al.’s experiments confirmed that the drug has been treated in the early stage of spinal cord injury (1h after injury) and in the later stage (4h after injury) Function and functional recovery were significantly higher than those in the control group.Stick Peters et al injected naloxone to 11 adult patients with septic shock who were not treated with traditional anti-shock therapy, of whom 8 received no corticosteroids.