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目的:探讨纤维蛋白原(Fib)在阑尾炎患者中的变化及其临床意义。方法:回顾性分析我院手术、病理证实的阑尾炎患者404例,按其分型分单纯组59例,化脓组263例,坏疽组82例,均采用全自动血凝仪检测Fib含量。结果:化脓组、坏疽组的Fib、WBC均高于单纯组,差异有统计学意义(P<0.01),而坏疽组Fib、WBC又高于化脓组,差异有统计学意义(P<0.01)。Fib与WBC相关性呈正相关(r=0.257,P<0.01)。结论:在阑尾炎时Fib、WBC变化是随病理分型而变化,病情越重Fib、WBC越高,故Fib与WBC一样对判断阑尾炎病情轻重及预分型有一定价值,有望为临床治疗决策提供参考依据。
Objective: To investigate the changes and clinical significance of fibrinogen (Fib) in patients with appendicitis. Methods: A total of 404 patients with appendicitis confirmed by surgery and pathology in our hospital were retrospectively analyzed. 59 cases were simple group, 263 cases were purulent group and 82 cases were gangrene group. Fib content was detected by automatic coagulation analyzer. Results: The Fib and WBC in pyogenic group and gangrene group were significantly higher than those in simple group (P <0.01), while those in gangrene group were higher than those in suppurative group (P <0.01) . There was a positive correlation between Fib and WBC (r = 0.257, P <0.01). Conclusion: The changes of Fib and WBC in appendicitis vary with the pathological classification. The more severe the disease is, the higher the Fib and the higher the WBC. Therefore, Fib and WBC have some value in judging the severity and pre-classification of appendicitis and are expected to provide clinical treatment decision-making Reference.