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目的探讨便携式凝血仪(POCT)在华法林抗凝治疗监测中的应用价值。方法选取2015年6-12月江门市蓬江区杜阮镇卫生院收治的30例行华法林抗凝治疗的静脉血栓栓塞症患者作为研究对象,分别采用POCT和实验室全自动凝血分析仪检测国际标准化比值(INR)。根据POCT和实验室INR检测结果将患者分为<2、2~3及>3组,比较POCT和实验室INR检测结果符合率及两种检测方法的相关性、偏倚度。结果 POCT和实验室检测INR在同一范围内的患者28例,符合率为93.3%(28/30);Bland-Al tman分析结果显示,POCT与实验室检测INR的相关决定系数r2=0.751,相关系数r=0.859(P<0.05),偏倚度为0.02±0.50,上限为0.49,下限为0.51。结论 POCT使用方便快捷,检测的INR与实验室检测的符合率高,具有相关性,且偏倚度低,可广泛应用于华法林抗凝治疗监测中。
Objective To investigate the value of portable coagulation analyzer (POCT) in the monitoring of warfarin anticoagulant therapy. Methods Thirty patients with venous thromboembolism treated with warfarin anticoagulation were enrolled in this study from June to December in 2015 in Du Ruan Township Hospital, Pengjiang District, Jiangmen City. The patients were randomly divided into three groups: POCT and laboratory automatic coagulation analyzer Standardized ratio (INR). The patients were divided into 2, 2, 3, and 3 groups according to POCT and laboratory INR test results. The correlation between POCT and laboratory INR test results and the correlation between the two test methods and the degree of bias were compared. Results The POCT and laboratory tests were performed in 28 patients with the same INR. The coincidence rate was 93.3% (28/30). The Bland-Altman analysis showed that the correlation coefficient between POCT and INR was 0.751 The coefficient r = 0.859 (P <0.05), the bias of 0.02 ± 0.50, the upper limit of 0.49 and the lower limit of 0.51. Conclusions POCT is convenient and quick to use. The detected INR has high coincidence rate with laboratory tests, and has a low degree of bias. It can be widely used in the monitoring of warfarin anticoagulant therapy.