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作者采用流式细胞技术,对24例新鲜速冻卵巢癌组织的细胞DNA含量及S期比例(SPF)进行了定量测定,分析了它们与患者年龄、临床分期、有无腹水、组织学分类、病理分级、肿瘤组织淋巴细胞浸润及砂粒体形成之间的关系。结果表明,卵巢癌细胞DNA含量和SPF与腹水有无及病理分级有明显的关系(P<0.05和P<0.01),有腹水、病理Ⅲ级和Ⅱ级的异倍体率及SPF均明显高于无腹水及病理Ⅰ级者。作者认为,卵巢癌细胞DNA含量和SPF可作为一个相对独立的反映卵巢癌细胞生物学行为的客观指标,对卵巢癌的早期诊断、治疗方案的选择和预后的估计有较大的辅助价值。
The authors used flow cytometry to quantify the cellular DNA content and S-phase fraction (SPF) of 24 fresh-frozen-phase ovarian cancer tissues and analyzed their relationship with age, clinical stage, presence of ascites, histological classification, pathology Grading, tumor tissue lymphocyte infiltration and the relationship between sand body formation. The results showed that DNA content and SPF in ovarian cancer cells were significantly correlated with the presence and absence of ascites and pathological grade (P <0.05 and P <0.01), with ascites, the level of aneuploidy and the SPF of pathological grade Ⅲ and Ⅱ were significantly higher No ascites and pathological grade Ⅰ. The authors believe that DNA content and SPF in ovarian cancer cells may serve as a relatively independent objective indicator of biological behavior of ovarian cancer cells and provide a valuable aid in the early diagnosis of ovarian cancer, the selection of treatment options and the estimation of prognosis.