论文部分内容阅读
目的探讨利奈唑胺滴眼液单次滴兔眼后在角膜中的药动学特征。方法 40只新西兰大白兔,局部滴入利奈唑胺滴眼液50μL,采用高效液相色谱法测定兔眼角膜中利奈唑胺的药物浓度,用DAS 2.1.1软件计算药动学参数。结果给药后0～120 h,利奈唑胺在兔眼角膜中的最高浓度为(58.62±15.48)μg.g 1,消除半衰期t1/2为(38.09±11.59)h,药时曲线下面积AUC0 t为(2 459.02±508.95)μg.h.g 1,AUC0∞为(2 834.13±578.96)μg.h.g 1。结论利奈唑胺滴眼液单次滴兔眼后在角膜中具有良好的药代动力学特征和组织通透性。
Objective To investigate the pharmacokinetics of linezolid in cornea after a single drop of rabbit eye. Methods Forty New Zealand rabbits were instilled with 50μL of linezolid, and the drug concentration of linezolid was measured by high performance liquid chromatography. The pharmacokinetic parameters were calculated by DAS 2.1.1 software. Results The highest concentration of linezolid was (58.62 ± 15.48) μg.g 1 and the elimination half-life t1 / 2 was (38.09 ± 11.59) h at 0-120 h after drug administration. The area under the curve of drug administration was AUC0 t was (2 459.02 ± 508.95) μg.hg 1, and AUC0∞ was (2 834.13 ± 578.96) μg.hg 1. Conclusion Linezolid drops have good pharmacokinetic characteristics and tissue permeability in the cornea after a single drop of rabbit eye.