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异烟肼是临床上最常用的一种抗结核药,为了提高疗效,防止毒及副作用的发生,常与其他药物配伍同服;但是,如配伍不当不但达不到预期的目的,反可降低疗效、增加毒性和副作用。一、影响胃肠道吸收的配伍用药:异烟肼抗结核杆菌的机理一般认为,首先与钙、铁等离子形成螯合物,然后再影响酶系统而发挥作用。同时,异烟肼还是一种螯合剂,与杆菌酶系统中的镁螯合,从而干扰了结核杆菌的代谢,抑制其生长。故在服用异烟肼的同时,不宜与含有钙、镁、铁、铝等金属离子的药物同服,因异烟肼可与一些金属离形成螯合物、减少在胃肠道中的吸收,降低其抗菌作用。如必须联用时,宜间隔3—4小时给药,同时也不要与活性炭、白陶土、矽酸银等同时给予、也不宜与食物同服。
Isoniazid is the most commonly used clinical anti-TB drugs, in order to improve the efficacy and prevent the occurrence of toxic and side effects, often with other drugs with the same service; However, such as improper compatibility not only failed to achieve the desired purpose, can be reduced Efficacy, increased toxicity and side effects. First, the impact of absorption of the gastrointestinal tract Compatibility Medication: Isoniazid Mycobacterium tuberculosis mechanism is generally believed that the first calcium and iron ions to form chelates, and then affect the enzyme system and play a role. At the same time, isoniazid is also a chelator that chelates magnesium in the bacitracin system, interfering with the metabolism of Mycobacterium tuberculosis and inhibiting its growth. Therefore, taking isoniazid at the same time, not with the calcium, magnesium, iron, aluminum and other metal ions in the same drug because isoniazid can form chelates with some metal to reduce the absorption in the gastrointestinal tract, reduce Its antibacterial effect. If it is necessary to be combined, it is advisable to administer drugs at intervals of 3-4 hours, meanwhile not to be given at the same time with activated carbon, kaolin clay, silver silicate and the like, nor should they be used with food.