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目的:研究急性百草枯中毒患者的百草枯含量、肾功能指标和肺功能指标与其预后关系。方法:选择107例急性百草枯中毒患者为研究对象,根据预后分为存活组和死亡组,检测患者血尿的百草枯含量、肾功能指标和肺功能指标。结果:死亡组患者的血浆百草枯含量、尿液百草枯含量分别为9.54±1.13mg/和423.23±63.43mg/L均高于存活组;血肌酐、血尿素氮、二氧化碳分压(PaCO2)分别为141.8±18.2mmol/L、11.4±2.2mmol/L和1.32±6.32mmHg,均高于存活组,氧分压(PaO2)、实际碳酸氢盐(PCO3-)和剩余碱(BE)分别为79.44±10.42mmHg、14.82±2.45mmol/L和(-14.56±3.42)mmol/L,均低于存活组(P<0.05)。结论:百草枯中毒患者的百草枯含量、肺功能和肾功能指标与其预后密切相关,百草枯含量、血肌酐、血尿素氮、PaCO2、剩余碱可提示患者的存活情况。
Objective: To study the relationship between paraquat content, renal function and pulmonary function in patients with acute paraquat poisoning. Methods: A total of 107 patients with acute paraquat poisoning were selected as study subjects. The patients were divided into survival group and death group according to the prognosis. Paraquat content, renal function and pulmonary function indexes were determined in patients with hematuria. Results: The plasma paraquat and paraquat concentrations in the death group were 9.54 ± 1.13 mg and 423.23 ± 63.43 mg / L, respectively, higher than those in the surviving group. The levels of serum creatinine, blood urea nitrogen, and partial pressure of carbon dioxide (PaCO2) Were 141.8 ± 18.2mmol / L, 11.4 ± 2.2mmol / L and 1.32 ± 6.32mmHg, respectively, which were higher than those in the survival group. PaO2, PCO3 and BE were 79.44 ± 10.42mmHg, 14.82 ± 2.45mmol / L and (-14.56 ± 3.42) mmol / L, respectively, all lower than those in survivors (P <0.05). CONCLUSION: The paraquat content, lung function and renal function of patients with paraquat poisoning are closely related to their prognosis. The paraquat content, serum creatinine, blood urea nitrogen, PaCO2 and residual alkali may indicate the patient’s survival.