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1957年Friou 等发表了以间接免疫荧光法检测抗核抗体(ANA)的论述,这对以后ANA 的研究起若重要的作用.不过,这一发现仅仅是一个ANA 的筛选试验,并没有对该物质的分类及鉴定做出研究.1966年Tan 等首先用免疫双扩散法发现系统性红斑狼疮(SLE)的标记抗体抗Sm 抗体以来,已相继发现了多达20余种的抗可溶性核抗原抗体(抗ENA 抗体).近10年来,随着免疫学及分子生物学理论及技术向风湿病学的渗透,已开始将免疫印迹法和免疫沉淀法应
In 1957 Friou et al published an indirect immunofluorescence assay antinuclear antibody (ANA) of the discussion, which ANA study later play an important role, but this finding is only an ANA screening test, and not the Classification and identification of substances to make a study.In 1966, Tan and other first identified by dual immunodiffusion immune system anti-Sm antibody labeled antibody to SLE, have been found up to more than 20 kinds of anti-soluble nuclear antigen antibody (Anti-ENA antibody) .In the past 10 years, with the immunology and molecular biology theory and technology to rheumatism penetration, immunoblotting and immunoprecipitation