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目的:观察抑火理脾颗粒剂对2型糖尿病患者血清胰高血糖素样肽-1(Glucagon-like peptide-1,GLP-1)水平的影响。方法:选取2015年1—12月南京市江宁区中医医院住院及门诊治疗的2型糖尿病患者120例,其中脱落6例,剔除1例,纳入统计分析者113例,随机分为治疗组57例和对照组56例。两组患者均给予糖尿病饮食、适量运动及诺和灵30R降糖等基础治疗,治疗组给予抑火理脾颗粒剂治疗,对照组给予抑火理脾颗粒剂安慰剂治疗。结果:治疗组治疗后空腹、餐后2h GLP-1水平均优于对照组,差异有统计学意义(P<0.05)。结论:抑火理脾颗粒剂可改善2型糖尿病患者空腹、餐后2h GLP-1水平。
Objective: To observe the effect of Suppressing Fire Suppressing Li and Spleen Granules on serum level of Glucagon-like peptide-1 (GLP-1) in type 2 diabetic patients. Methods: From January to December in 2015, Jiangning District Hospital of Nanjing, Nanjing Hospital, 120 outpatients and outpatients with type 2 diabetes mellitus, including 6 cases of shedding, excluding 1 case, included 113 cases of statistical analysis, were randomly divided into treatment group 57 cases And control group of 56 cases. Two groups of patients were given diabetes diet, moderate exercise and norepinephrine 30R hypoglycemic and other basic treatment, the treatment group was given fire suppression spleen granule treatment, the control group was given fire suppression spleen granules placebo treatment. Results: After treatment, the levels of fasting and postprandial 2-h GLP-1 in the treatment group were better than those in the control group, with significant difference (P <0.05). Conclusion: Inhibitory fire spleen granules can improve fasting and 2-hour postprandial GLP-1 level in type 2 diabetic patients.