目的探讨血清肿瘤标志物CEA、AFP、CA199、CA153、CA125检测在胃癌、食管癌、肝癌、胰腺癌、结肠癌、直肠癌诊断中的价值。方法应用ELISA法检测血清CEA、AFP、CA199、CA153、CA125水平。结果恶性肿瘤组显著高于非恶性肿瘤组,CEA对胃癌、食管癌、结肠癌、直肠癌的阳性率为49.3%,AFP对原发性肝癌的阳性率在81.8%,CA199在6例胰腺癌中的阳性率为100%,CA153、CA125对消化系统恶性肿瘤的阳性率在20%左右。结论CEA、AFP、CA199、CA153、CA125可作为消化系统恶性肿瘤的诊断指标。 Objective To investigate the diagnostic value of serum tumor markers CEA, AFP, CA199, CA153 and CA125 in gastric cancer, esophageal cancer, liver cancer, pancreatic cancer, colon cancer and rectal cancer. Methods Serum levels of CEA, AFP, CA199, CA153 and CA125 were measured by ELISA. Results The positive rate of CEA in gastric cancer, esophageal cancer, colon cancer and rectal cancer was 49.3%. The positive rate of AFP in primary liver cancer was 81.8%. The positive rate of CA199 in 6 cases of pancreatic cancer In the positive rate of 100%, CA153, CA125 digestive system malignant tumor positive rate of about 20%. Conclusion CEA, AFP, CA199, CA153, CA125 can be used as diagnostic indicators of digestive system malignancies.