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本文报告了用唛酚生治疗急性溴氰菊酯中毒大鼠的效果,结果表明:给大鼠以5mg/kg剂量溴氰菊酯静脉染毒未经治疗者均出现流涎、兴奋、舞蹈、扭动等典型的急性溴氰菊酯中毒症状,全部于半小时内死亡。用同等剂量染毒的动物,无论在中毒早期(流涎)还是晚期(舞蹈扭动)时,用唛酚生以每分钟4mg/kg速度静脉连续滴注治疗3小时(150mg),均有良好疗效。其中于中毒早期治疗者,全部未出现舞蹈扭动,停药后也未出现症状;且在3.5小时内全部恢复正常;中毒晚期治疗组,用药期间亦皆未出现运动症状,停药后半数动物于1小时内恢复正常,余半数动物虽死亡,但平均存活时间延长至650分钟。另一组于中毒早期滴注唛酚生(每分钟4mg/kg)持续仅1小时(50mg)的动物,全部未能挽救性命,说明该组治疗剂量不足。本文对唛酚生的疗效机制做了初步讨论。
This paper reports the effect of treatment of acute deltamethrin with Mark Phenol in rats, the results showed that: rats given 5mg / kg dose of deltamethrin intravenous administration were treated without salivation, excitement, dance, twist Moved and other typical symptoms of acute deltamethrin poisoning, all within half an hour of death. Animals exposed to the same dose had a good effect of intravenous infusion of 4 mg / kg IV for 3 hours (150 mg) at either the early (early or early) stage of choking (dance writhing) . Among them, the early treatment of poisoning, all did not appear dance twisting, no symptoms after stopping; and within 3.5 hours all returned to normal; late poisoning treatment group, during the medication are also without exercise symptoms, after stopping half animals Returned to normal within 1 hour, while the remaining half animals died, but the average survival time was extended to 650 minutes. Another group of animals that had been infused with Mark Phenol (4 mg / kg per minute) for only 1 hour (50 mg) in the early stages of the poisoning failed to save their lives, indicating that the group was under-treated. This article made a preliminary discussion of the therapeutic mechanism of Mark phenols.