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目的:观察D-二聚体,IL-1β和TNF-α水平在老年脑梗死继发癫痫患者中的意义。方法:选择2009年1月-2012年8月我院就诊的脑梗死患者110例,根据有无继发癫痫分为脑梗死癫痫组(65例)和单纯脑梗死组(45例)。选取同期健康体检者20例为健康对照组。分别检测各组血清D-二聚体,IL-1β和TNF-α水平。结果:D-二聚体,IL-1β和TNF-α水平脑梗死癫痫组和单纯脑梗死组较正常对照组明显提高(P<0.01),而脑梗死癫痫组较单纯脑梗死组提高更为明显(P<0.01)。65例脑梗死伴癫痫的患者中,正常范围者4例,轻度异常10例,中度异常30例,重度异常21例。而脑梗死癫痫组的D-二聚体,IL-1β和TNF-α水平随着脑电图严重程度增加而水平逐渐增高(P<0.01)。结论:D-二聚体,IL-1β和TNF-α可能参与了脑梗死继发癫痫的发病过程,是反映癫痫发病的严重程度的重要指标。
Objective: To observe the significance of D-dimer, IL-1β and TNF-α levels in patients with epilepsy secondary to senile cerebral infarction. Methods: One hundred and ten patients with cerebral infarction in our hospital from January 2009 to August 2012 were divided into epilepsy group (65 cases) and cerebral infarction group (45 cases) according to the presence or absence of secondary epilepsy. Select the same period of 20 healthy physical examination for the healthy control group. The levels of serum D-dimer, IL-1β and TNF-α were detected in each group. Results: The levels of D-dimer, IL-1β and TNF-α in cerebral infarction epilepsy group and simple cerebral infarction group were significantly higher than those in normal control group (P <0.01), while those in cerebral infarction epilepsy group were significantly higher than those in simple cerebral infarction group Obviously (P <0.01). Of the 65 patients with cerebral infarction and epilepsy, there were 4 patients with normal range, 10 with mild abnormality, 30 with moderate abnormality and 21 with severe abnormality. The levels of D-dimer, IL-1β and TNF-α in the epilepsy group increased gradually with the increase of the severity of electroencephalogram (P <0.01). Conclusion: D-dimer, IL-1β and TNF-α may play an important role in the pathogenesis of epilepsy secondary to cerebral infarction and reflect the severity of epilepsy.