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目的:探讨脑内微出血(CMB)在缺血性脑卒中患者中的发生及相关危险因素。方法:连续选取住院的缺血性脑卒中患者250例,分析其磁共振成像(MRI)表现。根据有无CMB将患者分为CMB组(80例)及无CMB组(170例)。详细记录临床资料,观察CMB的个数、陈旧性腔隙性脑梗死的个数和脑白质改变(WMC)的严重程度。结果:单因素分析显示年龄、高血压病、既往脑梗死病史、脑白质改变、陈旧性腔隙性脑梗死及口服抗血小板聚集药物史与CMB的发生有关。Logistic回归分析显示高血压、既往有脑梗死病史及WMC分值为CMB的独立危险因素。结论:CMB与脑微血管病变之间有密切关系,高血压、既往有脑梗死病史及WMC分值为缺血性脑卒中患者发生CMB的独立危险因素。
Objective: To investigate the occurrence and related risk factors of cerebral micro-hemorrhage (CMB) in patients with ischemic stroke. Methods: A total of 250 consecutive ischemic stroke patients were selected for analysis of their magnetic resonance imaging (MRI) performance. Patients were divided into CMB group (n = 80) and non-CMB group (n = 170) based on the presence or absence of CMB. The clinical data were recorded in detail. The number of CMB, the number of old lacunar infarcts and the severity of white matter changes (WMC) were observed. Results: Univariate analysis showed that age, hypertension, history of previous cerebral infarction, changes of white matter, lacunar lacunar infarction and oral antiplatelet drug were related to the occurrence of CMB. Logistic regression analysis showed that hypertension, previous history of cerebral infarction, and independent risk factors for WBC score of CMB. Conclusion: There is a close relationship between CMB and cerebral microangiopathy. Hypertension, past history of cerebral infarction and WMC score are independent risk factors of CMB in patients with ischemic stroke.