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血小板源性生长因子(Platelet-dirived growth factor,PDCF)是在血小板发生聚集反应时,由血小板α颗粒释放出的一种糖蛋白。能促进血管壁平滑肌细胞和成纤维细胞的增殖,对损伤的修复起重要作用。另一方面也提示了血小板中存在这样强力的生长因素,可能与某些血管病变有密切关系。本文介绍以PDGF为主的生长因子、并探讨其与某些血管病变的关系。Ⅰ.PDGF 1.PDGF的生物化学特征:PDGF由骨髓巨核细胞制造,贮存于血小板内并被带到血循环中。分子量为28.000～31.000,为等电点9.5～10.4的碱性蛋白质,含糖4～7%。是
Platelet-derived growth factor (PDCF) is a glycoprotein released from platelet alpha granules during platelet aggregation. Can promote the proliferation of vascular smooth muscle cells and fibroblasts play an important role in the repair of the injury. On the other hand also suggests that there is such a strong growth factor in platelets, may be closely related to certain vascular lesions. This article describes the PDGF-based growth factor and explore its relationship with some vascular lesions. I. PDGF 1. Biochemical Characteristics of PDGF: PDGF is made from bone marrow megakaryocytes, stored in platelets and taken to the bloodstream. The molecular weight is 28.000 ~ 31.000, the isoelectric point of 9.5 to 10.4 alkaline protein, sugar 4 ~ 7%. Yes